GENETIC-MAPPING OF 3 GABA(A) RECEPTOR-SUBUNIT GENES IN THE MOUSE

被引：25

作者：

DANCIGER, M

FARBER, DB

KOZAK, CA

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, JULES STEIN EYE INST, 100 STEIN PLAZA, LOS ANGELES, CA 90024 USA

[2] LOYOLA MARYMOUNT UNIV, LOS ANGELES, CA 90045 USA

[3] NIAID, BETHESDA, MD 20892 USA

来源：

GENOMICS | 1993年 / 16卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1198

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

GABAA receptors are a heterogeneous group of heterooligomeric ligand-gated anion channels that represent the main means of synaptic inhibition in neuronal tissue. At least 14 distinct GABAA subunit proteins representing 5 different classes have been identified. Using rat brain cDNAs for the GABAA receptor β1-, α2-, and α4-subunits, we have assigned the corresponding murine genes Gabrb-1, Gabra-2, and Gabra-4 to specific chromosomes with somatic cell hybrids, and we have positioned these genes by analysis of the progeny of three genetic crosses. Gabrb-1 and Gabra-2 are tightly linked on mouse Chromosome 5 between the markers Pgm-1 and Kit, and Gabra-4 maps to proximal mouse Chromosome 7 in apparent proximity to the previously mapped Gabrb-3. The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse “circling mutation” pi (pirouette). © 1993 Academic Press, Inc.

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页码：361 / 365

页数：5

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