Glucotoxicity and pancreatic proteomics

被引：46

作者：

Brunner, Yannick ^{[1
]}

Schvartz, Domitille ^{[1
]}

Priego-Capote, Feliciano ^{[1
]}

Coute, Yohann ^{[1
]}

Sanchez, Jean-Charles ^{[1
]}

机构：

[1] CMU, Biomed Proteom Res Grp, DBSB, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF PROTEOMICS | 2009年 / 71卷 / 06期

关键词：

Diabetes; Glucotoxicity; Proteomics; Mass spectrometry; ENDOPLASMIC-RETICULUM STRESS; GLYCATION END-PRODUCTS; BETA-CELL APOPTOSIS; 2-DIMENSIONAL GEL-ELECTROPHORESIS; INSULIN GENE-TRANSCRIPTION; NON ENZYMATIC GLYCATION; APOLIPOPROTEIN-A-I; ALPHA-LIPOIC ACID; OXIDATIVE STRESS; HIGH GLUCOSE;

D O I：

10.1016/j.jprot.2008.10.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic hyperglycaemia. is one of the main characteristics of a diabetic state. This is also the first cause of diabetic complications. However, it is now generally accepted that glucotoxicity also participates in the worsening of type 2 diabetes, by affecting the secretion of beta-cells. So far, different mechanisms have been proposed to explain the adverse effects of chronic hyperglycaemia. One of them suggests that the modulation of expression of several key proteins during a hyperglycaemia state, may explain the toxic effect of glucotoxicity. Therefore, proteomic analysis of biological samples represents an interesting method to study the effect of chronic hyperglycaemia on protein expression. The discovery of new proteins for which the expression could be modulated by chronic hyperglycaemia may probably help to better understand the mechanisms underlying glucotoxicity. In this review, we will first present an introduction of the different mechanisms known to be involved in the control of glucose homeostasis and in the development of glucotoxicity. in a second part, some proteomic data linked with the effect of glucotoxicity in pancreas, pancreatic islets and beta-cells will be presented and discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：576 / 591

页数：16

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