Galanin-acetylcholine interactions: Relevance to memory and Alzheimer's disease

被引：109

作者：

Crawley, JN

机构：

来源：

LIFE SCIENCES | 1996年 / 58卷 / 24期

关键词：

galanin; neuropeptide; acetylcholine; neurotransmitter release; learning and memory; Alzheimer's disease;

D O I：

10.1016/0024-3205(96)00093-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain and its projection areas in mammalian brain. Centrally administered galanin inhibits acetylcholine release in the rat ventral hippocampus, and produces deficits in learning and memory tasks. In Alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of Meynert cell bodies. Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias.

引用

收藏

页码：2185 / 2199

页数：15

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