Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase

被引：49

作者：

Fink, DM

Palermo, MG

Bores, GM

Huger, FP

Kurys, BE

Merriman, MC

Olsen, GE

Petko, W

OMalley, GJ

机构：

[1] Hoechst-Roussel Pharmaceuticals, Neuroscience TD, Somerville, NJ 08876

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00072-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates was prepared and evaluated as dual acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitors. Halogen substitution ortho to the carbamate functionality in the eight position resulted in a significant increase in binding affinity for both AChE and MAO-A.

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收藏

页码：625 / 630

页数：6

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