Deciphering the transcriptional network of the dendritic cell lineage

被引：588

作者：

Miller, Jennifer C. ^{[1
,2
]}

Brown, Brian D. ^{[1
,3
]}

Shay, Tal ^{[4
]}

Gautier, Emmanuel L. ^{[1
,5
,6
]}

Jojic, Vladimir ^{[7
]}

Cohain, Ariella ^{[3
]}

Pandey, Gaurav ^{[3
]}

Leboeuf, Marylene ^{[1
,2
]}

Elpek, Kutlu G. ^{[8
]}

Helft, Julie ^{[1
,2
]}

Hashimoto, Daigo ^{[1
,2
]}

Chow, Andrew ^{[1
,2
,9
]}

Price, Jeremy ^{[1
,2
]}

Greter, Melanie ^{[1
,2
,7
]}

Bogunovic, Milena ^{[1
,2
]}

Bellemare-Pelletier, Angelique ^{[8
]}

Frenette, Paul S. ^{[9
]}

Randolph, Gwendalyn J. ^{[1
,5
,6
]}

Turley, Shannon J. ^{[8
]}

Merad, Miriam ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA

[3] Mt Sinai Sch Med, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY USA

[4] Broad Inst, Cambridge, MA USA

[5] Mt Sinai Sch Med, Dept Regenerat Biol, New York, NY USA

[6] Washington Univ, Dept Pathol & Immunol, St Louis, MO USA

[7] Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA

[8] Dana Farber Canc Inst, Boston, MA 02115 USA

[9] Albert Einstein Coll Med, Bronx, NY 10467 USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 09期

基金：

美国国家卫生研究院;

关键词：

IN-VIVO; LYMPH-NODES; IMMUNE REGULATION; BONE-MARROW; FLT3; LIGAND; RECEPTOR; EXPRESSION; MICE; HETEROGENEITY; HEMATOPOIESIS;

D O I：

10.1038/ni.2370

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8(+), CD103(+), CD11b(+) and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.

引用

页码：888 / 899

页数：12

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