Targeted enzyme-responsive drug carriers: Studies on the delivery of a combination of drugs

被引：59

作者：

Lee, MR ^{[1
]}

Baek, KH ^{[1
]}

Jin, HJ ^{[1
]}

Jung, YG ^{[1
]}

Shin, I ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 13期

关键词：

combination therapy; drug delivery; enzymes; peptides;

D O I：

10.1002/anie.200353204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double whammy: Effective and selective killing of E. coli cells containing a specific enzyme was achieved by using targeted enzyme-responsive drug carriers (see picture) that release free drugs in a stringently controlled manner. The carrier lowered the effective concentration of drug needed to kill the bacteria. The system could also be modified to deliver a combination of two drugs.

引用

收藏

页码：1675 / 1678

页数：4

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