Integrating immunometabolism and macrophage diversity

被引：222

作者：

Artyomov, Maxim N. ^{[1
]}

Sergushichev, Alexey ^{[1
,2
]}

Schilling, Joel D. ^{[1
,3
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] ITMO Univ, Comp Technol Dept, St Petersburg 197101, Russia

[3] Washington Univ, Sch Med, Diabet Cardiovasc Dis Ctr, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

SEMINARS IN IMMUNOLOGY | 2016年 / 28卷 / 05期

关键词：

Inflammation; Metabolism; Glycolysis; Mitochondria; Nitric oxide; FATTY-ACID OXIDATION; DENDRITIC CELL; ITACONIC ACID; GENE-EXPRESSION; METABOLISM; SUCCINATE; ACTIVATION; GLUCOSE; ORIGIN; CANCER;

D O I：

10.1016/j.smim.2016.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has also been increasing. Factors such as cell origin and tissue localization are now recognized as important variables that influence macrophage biology. Whether different macrophage populations also have unique metabolic phenotypes has not been extensively explored. In this article, we will discuss the importance of understanding how macrophage origin can modulate metabolic programming and influence inflammatory responses. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：417 / 424

页数：8

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