Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

被引：1609

作者：

Gautier, Emmanuel L. ^{[1
,2
,3
]}

Shay, Tal ^{[6
]}

Miller, Jennifer ^{[2
,4
,5
]}

Greter, Melanie ^{[2
,4
,5
]}

Jakubzick, Claudia ^{[1
,2
]}

Ivanov, Stoyan ^{[3
]}

Helft, Julie ^{[2
,4
,5
]}

Chow, Andrew ^{[2
,4
,5
]}

Elpek, Kutlu G. ^{[7
,8
]}

Gordonov, Simon ^{[9
,10
]}

Mazloom, Amin R. ^{[9
,10
]}

Ma'ayan, Avi ^{[9
,10
]}

Chua, Wei-Jen ^{[3
]}

Hansen, Ted H. ^{[3
]}

Turley, Shannon J. ^{[7
,8
]}

Merad, Miriam ^{[2
,4
,5
]}

Randolph, Gwendalyn J. ^{[1
,2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[4] Mt Sinai Sch Med, Dept Med, New York, NY USA

[5] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY USA

[6] Broad Inst, Cambridge, MA USA

[7] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA USA

[8] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[9] Mt Sinai Sch Med, Dept Pharmacol, New York, NY USA

[10] Mt Sinai Sch Med, Syst Therapeut & Syst Biol Ctr New York, New York, NY USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DENDRITIC CELL; STEADY-STATE; BONE-MARROW; IN-VIVO; DIFFERENTIATION; HETEROGENEITY; PROGENITORS; HOMEOSTASIS; ACTIVATION; REVEALS;

D O I：

10.1038/ni.2419

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages rather than dendritic cells, and many of these were not present in all macrophages. Nonetheless, well-characterized surface markers, including MerTK and Fc gamma R1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages. TCEF3, C/EBP-alpha, Bach1 and CREG-1 were among the transcriptional regulators predicted to regulate these core macrophage-associated genes. The mRNA encoding other transcription factors, such as Gata6, was associated with single macrophage populations. We further identified how these transcripts and the proteins they encode facilitated distinguishing macrophages from dendritic cells.

引用

页码：1118 / 1128

页数：11

共 34 条

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