CTLA-4 and T cell activation

被引：166

作者：

Oosterwegel, MA ^{[1
]}

Greenwald, RJ ^{[1
]}

Mandelbrot, DA ^{[1
]}

Lorsbach, RB ^{[1
]}

Sharpe, AH ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Div Immunol Res, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(99)80047-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work,has. also revealed a role for CTLA-4 in regulating Th1/Th2 differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTLA-4 regulates both the initiation and the progression of autoimmune diseases.

引用

页码：294 / 300

页数：7

共 53 条

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