Mechanisms and models of somatic cell reprogramming

被引：361

作者：

Buganim, Yosef ^{[1
]}

Faddah, Dina A. ^{[1
,2
]}

Jaenisch, Rudolf ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS GENETICS | 2013年 / 14卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; GENE-EXPRESSION; C-MYC; COPY NUMBER; EPIGENETIC MEMORY; MOUSE FIBROBLASTS; NUCLEAR TRANSFER; DNA METHYLATION; DEFINED FACTORS; IPS CELLS;

D O I：

10.1038/nrg3473

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Conversion of somatic cells to pluripotency by defined factors is a long and complex process that yields embryonic-stem-cell-like cells that vary in their developmental potential. To improve the quality of resulting induced pluripotent stem cells (iPSCs), which is important for potential therapeutic applications, and to address fundamental questions about control of cell identity, molecular mechanisms of the reprogramming process must be understood. Here we discuss recent discoveries regarding the role of reprogramming factors in remodelling the genome, including new insights into the function of MYC, and describe the different phases, markers and emerging models of reprogramming.

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收藏

页码：427 / 439

页数：13

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