Synthesis of heterocycle substituted 1-aryl-4-piperidones

被引：15

作者：

Hu, BH ^{[1
]}

Malamas, M ^{[1
]}

Ellingboe, J ^{[1
]}

机构：

[1] Wyeth Res, Chem Sci, Collegeville, PA 19426 USA

来源：

HETEROCYCLES | 2002年 / 57卷 / 05期

关键词：

D O I：

10.3987/COM-02-9447

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of heterocycle substituted 1-aryl-4-piperidones were prepared via Knoevenagel condensations between nitrogen-containing 5-membered heterocycles and benzaldehyde (1) followed by reduction or amination. The oxadiazolidinedione ring was formed by reacting the N-hydroxyurea (10) with methyl chloroformate and sodium hydride.

引用

页码：857 / 870

页数：14

共 13 条

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