A new entry into 2-azabicyclo[2.1.1]hexanes via 3-(chloromethyl) cyclobutanone

被引：38

作者：

Stevens, C ^{[1
]}

DeKimpe, N ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,FAC AGR & APPL BIOL SCI,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 06期

关键词：

D O I：

10.1021/jo951865b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Azabicyclo[2.1.1]hexanes, which possess the skeleton of 2,4-methanoproline (a naturally occurring insect antifeedant), were synthesized by imination of the previously unknown 3-(chloromethyl)cyclobutanone and subsequent reductive cyclization. The precursor of the latter, 3-oxocyclobutane carboxylic acid, was prepared by two pathways in multigram quantities.

引用

页码：2174 / 2178

页数：5

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