mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

被引：106

作者：

Fendt, M. ^{[1
,2
]}

Schmid, S. ^{[2
]}

Thakker, D. R. ^{[1
]}

Jacobson, L. H. ^{[1
]}

Yamamoto, R. ^{[1
]}

Mitsukawa, K. ^{[1
]}

Maier, R. ^{[1
]}

Natt, F. ^{[3
]}

Huesken, D. ^{[3
]}

Kelly, P. H. ^{[1
]}

McAllister, K. H. ^{[1
]}

Hoyer, D. ^{[1
]}

van der Putten, H. ^{[1
]}

Cryan, J. F. ^{[1
]}

Flor, P. J. ^{[1
]}

机构：

[1] Novartis Pharma AG, Novartis Inst BioMed Res, Neurosci Res, CH-4002 Basel, Switzerland

[2] Univ Tubingen, Fak Biol, Inst Zool, Tubingen, Germany

[3] Novartis Pharma AG, Novartis Inst BioMed Res, Genome & Proteome Sci, CH-4002 Basel, Switzerland

来源：

MOLECULAR PSYCHIATRY | 2008年 / 13卷 / 10期

关键词：

anxiety; fear learning; glutamate; metabotropic glutamate receptors;

D O I：

10.1038/sj.mp.4002073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates.

引用

页码：970 / 979

页数：10

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