Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA

被引：165

作者：

Rahmati, S ^{[1
]}

Yang, S ^{[1
]}

Davidson, AL ^{[1
]}

Zechiedrich, EL ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

MOLECULAR MICROBIOLOGY | 2002年 / 43卷 / 03期

关键词：

D O I：

10.1046/j.1365-2958.2002.02773.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SdiA is an Escherichia coli protein that regulates cell division in a cell density-dependent, or quorum-sensing, manner. We report that SdiA also controls multidrug resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction of SdiA confers multidrug resistance and increased levels of AcrAB. Conversely, sdiA null mutants are hypersensitive to drugs and have decreased levels of AcrB protein. Our findings provide a link between quorum sensing and multidrug efflux. Combined with previously published reports, our data support a model in which a role of drug efflux pumps is to mediate cell-cell communication in response to cell density. Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux.

引用

页码：677 / 685

页数：9

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