Enzymatic Release of a Surface-Adsorbed RGD Therapeutic from a Cleavable Peptide Anchor

被引：8

作者：

Meyers, Steven R. ^{[1
,2
,3
]}

Kenan, Daniel J.

Grinstaff, Mark W. ^{[1
,2
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[2] Boston Univ, Dept Chem, Boston, MA 02215 USA

[3] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

来源：

CHEMMEDCHEM | 2008年 / 3卷 / 11期

关键词：

adsorption; biomimetic device modification; drug delivery; enzymes; peptides;

D O I：

10.1002/cmdc.200800205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(Figure Presented) Implanted medical devices inevitably promote inflammation of the surrounding tissue. A method for enzymatically triggered localized drug delivery would have marked benefits in dealing with this response. Herein we present a rationally designed peptide coating for use with medical devices such as stents, that contains three distinct domains: 1) an implant-adsorptive sequence, 2) an enzymatically cleavable release mechanism, and 3) a therapeutic to be delivered. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：1645 / 1648

页数：4

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