Transport of the antibacterial agent (6S)-6-fluoroshikimate and other shikimate analogues by the shikimate transport system of Escherichia coli

被引：12

作者：

Jude, DA ^{[1
]}

Ewart, CDC ^{[1
]}

Thain, JL ^{[1
]}

Davies, GM ^{[1
]}

Nichols, WW ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,DEPT INFECT RES,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1996年 / 1279卷 / 02期

关键词：

fluoroshikimate; shiA; shikimate transport; antibacterial agent;

D O I：

10.1016/0005-2736(95)00295-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show that the antibacterial agent, (6S)-6-fluoroshikimate, is a substrate for the shikimate transport system of Escherichia coli because in exchange-diffusion experiments it displaced intracellular [C-14]shikimate with the same kinetics as did unlabelled shikimate. Other shikimate analogues were also substrate: as judged by similar experiments or, in the case of (6R)-6-fluoroshikimate, by inference.

引用

页码：125 / 129

页数：5

共 12 条

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