The production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi

被引：93

作者：

Joosten, Vivi ^{[1
]}

Lokman, Christien ^{[1
]}

van den Hondel, Cees A. M. J. J. ^{[1
]}

Punt, Peter J. ^{[1
]}

机构：

[1] TNO Nutr & Food Res, Dept Appl Microbiol & Gene Technol, NL-3700 AJ Zeist, Netherlands

来源：

MICROBIAL CELL FACTORIES | 2003年 / 2卷 / 1期

关键词：

Filamentous Fungus; Antibody Fragment; Recombinant Antibody; Variable Light; Magic Bullet;

D O I：

10.1186/1475-2859-2-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this review we will focus on the current status and views concerning the production of antibody fragments and antibody fusion proteins by yeasts and filamentous fungi. We will focus on single-chain antibody fragment production (scFv and V-HH) by these lower eukaryotes and the possible applications of these proteins. Also the coupling of fragments to relevant enzymes or other components will be discussed. As an example of the fusion protein strategy, the 'magic bullet' approach for industrial applications, will be highlighted.

引用

页数：15

共 169 条

[1] Modifying secretion and post-translational processing in insect cells [J].

Ailor, E ;

Betenbaugh, MJ .

CURRENT OPINION IN BIOTECHNOLOGY, 1999, 10 (02) :142-145

[2] LUMINOL CHEMILUMINESCENCE REACTION CATALYZED BY A MICROBIAL PEROXIDASE [J].

AKIMOTO, K ;

SHINMEN, Y ;

SUMIDA, M ;

ASAMI, S ;

AMACHI, T ;

YOSHIZUMI, H ;

SAEKI, Y ;

SHIMIZU, S ;

YAMADA, H .

ANALYTICAL BIOCHEMISTRY, 1990, 189 (02) :182-185

[3] STRATEGIES FOR IMPROVING HETEROLOGOUS PROTEIN-PRODUCTION FROM FILAMENTOUS FUNGI [J].

ARCHER, DB ;

JEENES, DJ ;

MACKENZIE, DA .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 1994, 65 (03) :245-250

[4] scFv multimers of the anti-neuraminidase antibody NC10:: length of the linker between VH and VL domains dictates precisely the transition between diabodies and triabodies [J].

Atwell, JL ;

Breheney, KA ;

Lawrence, LJ ;

McCoy, AJ ;

Kortt, AA ;

Hudson, PJ .

PROTEIN ENGINEERING, 1999, 12 (07) :597-604

[5]

Beggs T, 1995, Oral compositions, Patent No. [WO 95/01155, 9501155]

[6] BACULOVIRUS EXPRESSION OF A FUNCTIONAL SINGLE-CHAIN IMMUNOGLOBULIN AND ITS IL-2 FUSION PROTEIN [J].

BEI, R ;

SCHLOM, J ;

KASHMIRI, SVS .

JOURNAL OF IMMUNOLOGICAL METHODS, 1995, 186 (02) :245-255

[7] ESCHERICHIA-COLI SECRETION OF AN ACTIVE CHIMERIC ANTIBODY FRAGMENT [J].

BETTER, M ;

CHANG, CP ;

ROBINSON, RR ;

HORWITZ, AH .

SCIENCE, 1988, 240 (4855) :1041-1043

[8] Heterologous biopharmaceutical protein expression in Streptomyces [J].

Binni, C ;

Cossar, JD ;

Stewart, DIH .

TRENDS IN BIOTECHNOLOGY, 1997, 15 (08) :315-320

[9] SINGLE-CHAIN ANTIGEN-BINDING PROTEINS [J].

BIRD, RE ;

HARDMAN, KD ;

JACOBSON, JW ;

JOHNSON, S ;

KAUFMAN, BM ;

LEE, SM ;

LEE, T ;

POPE, SH ;

RIORDAN, GS ;

WHITLOW, M .

SCIENCE, 1988, 242 (4877) :423-426

[10] Construction, expression and characterisation of a single chain anti-tumour antibody (scFv)-IL-2 fusion protein [J].

Boleti, E ;

Deonarain, MP ;

Spooner, RA ;

Smith, AJ ;

Epenetos, AA ;

George, AJT .

ANNALS OF ONCOLOGY, 1995, 6 (09) :945-947

← 1 2 3 4 5 6 7 8 9 10 →