Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

被引：38

作者：

Lau, Shing-Hing ^{[1
]}

Galvan, Alicia ^{[1
]}

Merchant, Rohan R. ^{[1
]}

Battilocchio, Claudio ^{[1
]}

Souto, Jose A. ^{[1
,2
]}

Berry, Malcolm B. ^{[3
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Univ Vigo, Dept Quim Organ, Vigo 36310, Spain

[3] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

ARTEMISININ; CHEMISTRY; INTENSIFICATION; MEDICINES; OZONIDES;

D O I：

10.1021/acs.orglett.5b01307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.

引用

页码：3218 / 3221

页数：4

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