The direct α-C(sp3)-H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing

被引：55

作者：

Brzozowski, Martin ^{[1
]}

Forni, Jose A. ^{[1
]}

Savage, G. Paul ^{[1
]}

Polyzos, Anastasios ^{[1
]}

机构：

[1] CSIRO Mfg Flagship, Clayton, Vic 3168, Australia

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 02期

关键词：

SP(3) C-H; DEHYDROGENATIVE COUPLING CDC; MOLECULAR-OXYGEN; TERTIARY-AMINES; BOND ACTIVATION; GLYCINE DERIVATIVES; OXIDATIVE CYANATION; DIRECT INDOLATION; FACILE SYNTHESIS; GASEOUS AMMONIA;

D O I：

10.1039/c4cc07913b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient nitro-Mannich type direct alpha-C(sp(3))-H functionalisation of N-aryl-1,2,3,4-tetrahydroisoquinolines catalysed by simple iron salts in combination with O-2 as the terminal oxidant is described. The use of a Teflon AF-2400 membrane Tube-in-Tube reactor under continuous flow conditions allowed for considerable process intensification to be achieved relative to previous batch methods.

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页码：334 / 337

页数：4

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