IL-18 receptor expression on epithelial cells is upregulated by TNF alpha

被引：13

作者：

Krásná, E ^{[1
]}

Kolesár, L ^{[1
]}

Slavcev, A ^{[1
]}

Valhová, S ^{[1
]}

Kronosová, B ^{[1
]}

Jaresová, M ^{[1
]}

Stríz, I ^{[1
]}

机构：

[1] Inst Clin & Expt Med IKEM, Dept Immunol, Prague 14021 4, Czech Republic

来源：

INFLAMMATION | 2005年 / 29卷 / 01期

关键词：

IL-18; IL-18R; epithelial cells; cytokines;

D O I：

10.1007/s10753-006-8967-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release.

引用

页码：33 / 37

页数：5

共 23 条

[1] Interleukin-18 expression and modulation in human corneal epithelial cells
Burbach, GJ
Naik, SM
Harten, JB
Liu, L
Dithmar, S
Grossniklaus, H
Ward, SL
Armstrong, CA
Caughman, SW
Ansel, JC
[J]. CURRENT EYE RESEARCH, 2001, 23 (01) : 64 - 68
[2] Airway epithelium expresses interleukin-18
Cameron, LA
Taha, RA
Tsicopoulos, A
Kurimoto, M
Olivenstein, R
Wallaert, B
Minshall, EM
Hamid, QA
[J]. EUROPEAN RESPIRATORY JOURNAL, 1999, 14 (03) : 553 - 559
[3] Expression of interleukin-18, interferon-γ and interleukin-10 in hepatocellular carcinoma
Chia, CS
Ban, K
Ithnin, H
Singh, H
Krishnan, R
Mokhtar, S
Malihan, N
Seow, HF
[J]. IMMUNOLOGY LETTERS, 2002, 84 (03) : 163 - 172
[4] Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation
De Perrot, M
Sekine, Y
Fischer, S
Waddell, TK
McRae, K
Liu, MY
Wigle, DA
Keshavjee, S
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (02) : 211 - 215
[5] Interleukin-18 and host defense against infection
Dinarello, CA
Fantuzzi, G
[J]. JOURNAL OF INFECTIOUS DISEASES, 2003, 187 : S370 - S384
[6] IL-18:: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
Dinarello, CA
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (01) : 11 - 24
[7] Role of IL-18 in CD4+ T lymphocyte activation in sarcoidosis
Greene, CM
Meachery, G
Taggart, CC
Rooney, CP
Coakley, R
O'Neill, SJ
McElvaney, NG
[J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (08) : 4718 - 4724
[8] Elevation of IL-18 in human sepsis
Grobmyer, SR
Lin, E
Lowry, SF
Rivadeneira, DE
Potter, S
Barie, PS
Nathan, CF
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2000, 20 (03) : 212 - 215
[9] The role of innate cytokines in inflammatory response
Liew, FY
[J]. IMMUNOLOGY LETTERS, 2003, 85 (02) : 131 - 134
[10] Constitutive expression of Interleukin-18 and Interleukin-18 receptor mRNA in tumour derived human B-cell lines
Lorey, SL
Huang, YC
Sharma, V
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 136 (03) : 456 - 462

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