Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes

被引：544

作者：

Cerutti, Andrea ^{[1
,2
,3
]}

Cols, Montserrat ^{[2
]}

Puga, Irene ^{[3
]}

机构：

[1] Catalan Inst Res & Adv Studies ICREA, Barcelona 08003, Spain

[2] Mt Sinai Sch Med, Dept Med, Inst Immunol, New York, NY 10029 USA

[3] Inst Hosp del Mar Invest Mediques IMIM, Barcelona 08003, Spain

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 02期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

VARIABLE REGION GENES; DENDRITIC CELLS; GERMINAL-CENTERS; STREPTOCOCCUS-PNEUMONIAE; SOMATIC HYPERMUTATION; INTESTINAL BACTERIA; HUMAN SPLEEN; TRANSMEMBRANE ACTIVATOR; POSITIVE SELECTION; PLASMA-CELLS;

D O I：

10.1038/nri3383

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the circulation and lymphoid tissue, splenic marginal zone B cells rapidly respond to blood-borne antigens by adopting 'crossover' defensive strategies that blur the conventional boundaries of innate and adaptive immunity. This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and T cell-independent antigens. These responses require the integration of activation signals from germline-encoded and somatically recombined receptors for microorganisms with helper signals from effector cells of the innate and adaptive immune systems.

引用

页码：118 / 132

页数：15

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