Catalytic promiscuity and the evolution of new enzymatic activities

被引：625

作者：

O'Brien, PJ ^{[1
]}

Herschlag, D ^{[1
]}

机构：

[1] Stanford Univ, Beckman Ctr B400, Dept Biochem, Stanford, CA 94305 USA

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1074-5521(99)80033-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

引用

页码：R91 / R105

页数：15

共 146 条

[1] EVOLUTIONARY RELATIONSHIPS AMONG PYRIDOXAL-5'-PHOSPHATE-DEPENDENT ENZYMES - REGIO-SPECIFIC ALPHA-FAMILY, BETA-FAMILY, AND GAMMA-FAMILY [J].

ALEXANDER, FW ;

SANDMEIER, E ;

MEHTA, PK ;

CHRISTEN, P .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 219 (03) :953-960

[2]

[Anonymous], 1986, J CONSUM MARK

[3] The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold [J].

Aravind, L ;

Galperin, MY ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (04) :127-129

[4] A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease [J].

Aravind, L ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (01) :17-19

[5] Mechanistic imperatives for the evolution of glutathione transferases [J].

Armstrong, RN .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (05) :618-623

[6] THE REACTIVITY OF PARA-NITROPHENYL ACETATE WITH SERUM ALBUMINS [J].

AWADELKARIM, A ;

MEANS, GE .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1988, 91 (02) :267-272

[7] FUNCTIONALLY DIVERSE ENZYME SUPERFAMILY THAT ABSTRACTS THE ALPHA-PROTONS OF CARBOXYLIC-ACIDS [J].

BABBITT, PC ;

MRACHKO, GT ;

HASSON, MS ;

HUISMAN, GW ;

KOLTER, R ;

RINGE, D ;

PETSKO, GA ;

KENYON, GL ;

GERLT, JA .

SCIENCE, 1995, 267 (5201) :1159-1161

[8] The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids [J].

Babbitt, PC ;

Hasson, MS ;

Wedekind, JE ;

Palmer, DRJ ;

Barrett, WC ;

Reed, GH ;

Rayment, I ;

Ringe, D ;

Kenyon, GL ;

Gerlt, JA .

BIOCHEMISTRY, 1996, 35 (51) :16489-16501

[9] Understanding enzyme superfamilies - Chemistry as the fundamental determinant in the evolution of new catalytic activities [J].

Babbitt, PC ;

Gerlt, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30591-30594

[10] Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis [J].

Baker, AS ;

Ciocci, MJ ;

Metcalf, WW ;

Kim, J ;

Babbitt, PC ;

Wanner, BL ;

Martin, BM ;

Dunaway-Mariano, D .

BIOCHEMISTRY, 1998, 37 (26) :9305-9315

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