Catalytic promiscuity and the evolution of new enzymatic activities

被引：625

作者：

O'Brien, PJ ^{[1
]}

Herschlag, D ^{[1
]}

机构：

[1] Stanford Univ, Beckman Ctr B400, Dept Biochem, Stanford, CA 94305 USA

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1074-5521(99)80033-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

引用

页码：R91 / R105

页数：15

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