Excitatory effects of 5-hydroxytryptamine on the medial vestibular nuclear neuron via the 5-HT2 receptor

被引：9

作者：

Jeong, HS

Lim, YC

Kim, TS

Heo, T

Jung, SM

Cho, YB

Jun, JY

Park, JS ^{[1
]}

机构：

[1] Chonnam Natl Univ, Sch Med, Dept Physiol, Kwangju 501190, South Korea

[2] Chonnam Natl Univ, Sch Med, Dept Pharmacol, Kwangju 501190, South Korea

[3] Chonnam Natl Univ, Sch Med, Dept Neurosurg, Kwangju 501190, South Korea

[4] Chonnam Natl Univ, Sch Med, Dept Emergency Med, Kwangju 501190, South Korea

[5] Chonnam Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Kwangju 501190, South Korea

[6] Univ Ulsan, Coll Med, Dept Diagnost Radiol, Kangnung 210711, South Korea

[7] Chosun Univ, Coll Med, Dept Physiol, Kwangju 501759, South Korea

来源：

NEUROREPORT | 2003年 / 14卷 / 15期

关键词：

5-hydroxytryptamine; medial vestibular nucleus; potassium current;

D O I：

10.1097/00001756-200310270-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study was designed to investigate the mechanisms of action of the 5-HT2 receptor on the spontaneous electrical activity and potassium currents of the rat medial vestibular nuclear neurons using whole-cell patch clamp recordings. The spike width of spontaneous action potential was not affected by 5 -alpha-methylhydroxytryptamine. The spike frequency and resting membrane potential was increased by 5-alpha-methylhydroxytryptamine. The amplitude of afterhyperpolarization was decreased by 5-alpha-methylhydroxy-tryptamine. The peak current of the potassium currents of the neuron treated with 5-alpha-methylhydroxytryptamine was decreased. After blockade of calcium-dependent potassium currents, 5-alpha-methylhydroxytryptamine did not inhibit potassium currents. These results suggest 5-alpha-methylhydroxytryptamine increases spontaneous firing of the medial vestibular nuclear neurons by inhibiting calcium dependent potassium currents.

引用

页码：2001 / 2004

页数：4