Regulation of fetal gene expression in heart failure

被引：216

作者：

Dirkx, Ellen ^{[1
,2
]}

da Costa Martins, Paula A. ^{[1
]}

De Windt, Leon J. ^{[1
]}

机构：

[1] Maastricht Univ, Fac Hlth Med & Life Sci, CARIM Sch Cardiovasc Dis, Dept Cardiol, Maastricht, Netherlands

[2] Royal Netherlands Acad Sci, ICIN Netherlands Heart Inst, Utrecht, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2013年 / 1832卷 / 12期

基金：

欧洲研究理事会;

关键词：

Gene regulation; Transcription factors; Epigenetics; SERUM RESPONSE FACTOR; CARDIAC TRANSCRIPTION FACTOR; ATRIAL SEPTAL-DEFECT; CALCINEURIN-INTERACTING PROTEIN-1; SINGLE-NUCLEOTIDE POLYMORPHISMS; LEFT-VENTRICULAR HYPERTROPHY; BONE MORPHOGENETIC PROTEIN; MYOCYTE ENHANCER FACTOR-2; II HISTONE DEACETYLASES; NATRIURETIC-FACTOR GENE;

D O I：

10.1016/j.bbadis.2013.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

During the processes leading to adverse cardiac remodeling and heart failure, cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating pathways that induce pathological hypertrophy. The gene expression patterns and molecular changes observed during cardiac hypertrophic remodeling bare resemblance to those observed during fetal cardiac development. The re-activation of fetal genes in the adult failing heart is a complex biological process that involves transcriptional, posttranscriptional and epigenetic regulation of the cardiac genome. In this review, the mechanistic actions of transcription factors, microRNAs and chromatin remodeling processes in regulating fetal gene expression in heart failure are discussed. (C) 2013 Elsevier B.V. All rights reserved.

引用

收藏

页码：2414 / 2424

页数：11

相关论文

共 193 条

[1]

Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1 [J].

Abbasi, S ;

Lee, JD ;

Su, B ;

Chen, X ;

Alcon, JL ;

Yang, JH ;

Kellems, RE ;

Xia, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (12) :7717-7726

[2]

Sirt1 regulates aging and resistance to oxidative stress in the heart [J].

Alcendor, Ralph R. ;

Gao, Shumin ;

Zhai, Peiyong ;

Zablocki, Daniela ;

Holle, Eric ;

Yu, Xianzhong ;

Tian, Bin ;

Wagner, Thomas ;

Vatner, Stephen F. ;

Sadoshima, Junichi .

CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521

[3]

Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes [J].

Alcendor, RR ;

Kirshenbaum, LA ;

Imai, S ;

Vatner, SF ;

Sadoshima, J .

CIRCULATION RESEARCH, 2004, 95 (10) :971-980

[4]

Serum response factor is essential for mesoderm formation during mouse embryogenesis [J].

Arsenian, S ;

Weinhold, B ;

Oelgeschläger, M ;

Rüther, U ;

Nordheim, A .

EMBO JOURNAL, 1998, 17 (21) :6289-6299

[5]

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes [J].

Balza, RO ;

Misra, RP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (10) :6498-6510

[6]

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways [J].

Benson, DW ;

Silberbach, GM ;

Kavanaugh-McHugh, A ;

Cottrill, C ;

Zhang, YZ ;

Riggs, S ;

Smalls, O ;

Johnson, MC ;

Watson, MS ;

Seidman, JG ;

Seidman, CE ;

Plowden, J ;

Kugler, JD .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (11) :1567-1573

[7]

Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[8]

Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure [J].

Bisping, Egbert ;

Ikeda, Sadakatsu ;

Kong, Sek Won ;

Tarnavski, Oleg ;

Bodyak, Natalya ;

McMullen, Julie R. ;

Rajagopal, Satish ;

Son, Jennifer K. ;

Ma, Qing ;

Springer, Zhangli ;

Kang, Peter M. ;

Izumo, Seigo ;

Pu, William T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (39) :14471-14476

[9]

Diffierential gene expression and genomic patient stratification following left ventricular assist device support [J].

Blaxall, BC ;

Tschannen-Moran, BM ;

Milano, CA ;

Koch, WJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (07) :1096-1106

[10]

Myocardial fibrosis in transforming growth factor β1 heterozygous mice [J].

Brooks, WW ;

Conrad, CH .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2000, 32 (02) :187-195

← 1 2 3 4 5 6 7 8 9 10 →