Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides

被引：38

作者：

Luzhetskyy, A

Vente, A

Bechthold, A

机构：

[1] Univ Freiburg, Inst Pharmazeut Wissensch, D-79104 Freiburg, Germany

[2] Combinature Biopharm AG, D-13125 Berlin, Germany

来源：

MOLECULAR BIOSYSTEMS | 2005年 / 1卷 / 02期

关键词：

D O I：

10.1039/b503215f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A unique characteristic of carbohydrates is their structural diversity which is greater than that of many other classes of biological compounds. Carbohydrate-containing natural products show many different biological activities and some of them have been developed as drugs for medical use. The biosynthesis of carbohydrate-containing natural products is catalysed by glycosyltransferases. In this review we will present information oil the function of glycosyltransferases involved in the biosynthesis of oligosaccharide antibiotics focusing especially on urdamycins and landomycins, two angucycline antibiotics with interesting antitumor activities. We will also discuss the use of glycosyltransferases in combinatorial biosynthesis to generate new "hybrid" antibiotics.

引用

页码：117 / 126

页数：10

共 46 条

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