Multiple Contrast Tests in the Presence of Heteroscedasticity

被引：80

作者：

Hasler, Mario ^{[1
]}

Hothorn, Ludwig A. ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Biostat, D-30419 Hannover, Germany

来源：

BIOMETRICAL JOURNAL | 2008年 / 50卷 / 05期

关键词：

Familywise error rate; Heteroscedasticity; Multiple contrast tests; Multivariate t-distribution; Simultaneous confidence intervals;

D O I：

10.1002/bimj.200710466

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper proposes a general approach for handling multiple contrast tests for normally distributed data in the presence of heteroscedasticity. Three candidate procedures are described and compared by simulations. Only the procedure with both comparison-specific degrees of freedom and a correlation matrix depending on sample variances maintains the alpha-level over all situations. Other approaches may fail notably as the variances differ more. Furthermore, related approximate simultaneous confidence intervals are given. The approach will be applied to a toxicological experiment.

引用

页码：793 / 800

页数：8

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