Clinical MRI for iron detection in Parkinson's disease

被引：69

作者：

Rossi, Maija ^{[1
]}

Ruottinen, Hanna ^{[2
]}

Soimakallio, Seppo ^{[1
,3
]}

Elovaara, Irina ^{[2
,3
]}

Dastidar, Prasun ^{[1
,3
]}

机构：

[1] Tampere Univ Hosp, Dept Radiol, Med Imaging Ctr, Tampere 33520, Finland

[2] Tampere Univ Hosp, Dept Neurol & Rehabil, Tampere 33520, Finland

[3] Univ Tampere, Tampere Med Sch, FIN-33101 Tampere, Finland

来源：

CLINICAL IMAGING | 2013年 / 37卷 / 04期

关键词：

Iron; Magnetic resonance imaging; Parkinson's disease; MULTIPLE SYSTEM ATROPHY; MAGNETIC-RESONANCE; BRAIN IRON; BASAL GANGLIA; SUBSTANTIA-NIGRA; HEALTHY-SUBJECTS; SIGNAL CHANGES; ECHO SEQUENCE; 3.0; T; DEPOSITION;

D O I：

10.1016/j.clinimag.2013.02.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T-2-weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment. (c) 2013 Elsevier Inc. All rights reserved.

引用

收藏

页码：631 / 636

页数：6

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