Loss of heterozygosity in the VNTR region of intron 1 of p53 in two retinoblastoma cases

被引：2

作者：

Emre, S

Sungur, A

Bilgic, S

Buyukpamukcu, M

Gunalp, I

Ozguc, M

机构：

[1] HACETTEPE UNIV,FAC MED,DEPT PATHOL,ANKARA,TURKEY

[2] HACETTEPE UNIV,FAC MED,DEPT OPHTHALMOL,ANKARA 06100,TURKEY

[3] HACETTEPE UNIV,FAC MED,DEPT ONCOL,ANKARA 06100,TURKEY

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1996年 / 13卷 / 03期

关键词：

loss of heterozygosity; p53; retinoblastoma primary tumor; VNTR;

D O I：

10.3109/08880019609030824

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumours. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.

引用

页码：253 / 256

页数：4

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