The knowns and unknowns of the immunopathogenesis of tuberculosis

被引：38

作者：

Ottenhoff, T. H. M. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2012年 / 16卷 / 11期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Mycobacterium tuberculosis; immunopathogenic mechanisms; immunopathology; CD8; T-CELLS; RECONSTITUTION INFLAMMATORY SYNDROME; MYCOBACTERIUM-TUBERCULOSIS; IMMUNE-RESPONSE; ANTIGEN PRESENTATION; BCG VACCINATION; HIV-1-INFECTED PATIENTS; CYTOKINE PROFILES; INFECTION; DISEASE;

D O I：

10.5588/ijtld.12.0479

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In this review, we discuss the 'knowns' and 'unknowns' of host defence towards Mycobacterium tuberculosis. With regard to the 'knowns', both protective and immunopathogenic mechanisms are discussed, including recently discovered new pathways of host defence and inflammatory immunopathology. With regard to the 'unknowns', there will be emphasis on unanswered key questions, accompanied by a perspective on needs and priorities for future research. The role of the inflammatory response and its dysregulation in tuberculosis-related immune reconstitution inflammatory syndrome will also be discussed.

引用

页码：1424 / 1432

页数：9

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