Low dose of lipopolysaccharide induces a delayed enhanced nitric oxide-mediated relaxation in rat aorta

被引：14

作者：

Pu, Q

Bordet, R

Robin, E

Puisieux, F

Vallet, B

Dupuis, B

机构：

[1] Fac Med Lille, Pharmacol Lab, F-59045 Lille, France

[2] CH&U, Dept Anesthesie Reanimat, Lille, France

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 377卷 / 2-3期

关键词：

lipopolysaccharide; aortic ring; endothelium; vasorelaxation; N-omega-monomethyl-L-arginine;

D O I：

10.1016/S0014-2999(99)00420-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Delayed effect on vascular reactivity of isolated aorta was studied after injection of a single low dose of lipopolysaccharide (0.5 mg/kg i.p.). The maximal vascular effect was observed 72 h after lipopolysaccharide administration with an increase in maximal endothelium-dependent relaxing response to acetylcholine and parallelly a decrease in contractile response to phenylephrine. The change in contractile response was nullified by endothelium removal as well by in vitro aortic rings incubation with N-omega-monomethyl-L-arginine but not with indomethacin. A low dose of lipopolysaccharide induces a delayed enhanced nitric oxide-mediated vascular relaxation which could contribute to its delayed anti-ischemic properties in ischemic tolerance phenomenon. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：209 / 214

页数：6

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