Connecting COX-2 and Wnt in cancer

被引：101

作者：

Buchanan, FG ^{[1
]}

DuBois, RN ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

CANCER CELL | 2006年 / 9卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2005.12.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Both the cyclooxygenase-2 (COX-2) and Writ signaling cascades are active in the majority of colorectal cancers. Nevertheless, a direct link between these two key pathways has remained elusive. Recent reports show that one of the bioactive products of COX-2, prostaglandin E-2, activates components of the canonical Writ signaling system. The findings reviewed below reveal important crosstalk between these pathways, which may provide opportunities for the development of new drugs for treatment and/or prevention of colorectal cancer.

引用

页码：6 / 8

页数：3

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