Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

被引：124

作者：

Aldini, Giancarlo ^{[1
]}

Vistoli, Giulio ^{[1
]}

Stefek, Milan ^{[2
]}

Chondrogianni, N. ^{[3
]}

Grune, Tilman ^{[4
]}

Sereikaite, Jolanta ^{[5
]}

Sadowska-Bartosz, Izabela ^{[6
]}

Bartosz, Grzegorz ^{[6
,7
]}

机构：

[1] Univ Milan, Dept Pharmaceut Sci, Milan, Italy

[2] Slovak Acad Sci, Inst Expt Pharmacol, Bratislava 84216, Slovakia

[3] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece

[4] Univ Jena, Jena, Germany

[5] Vilnius Gediminas Tech Univ, Vilnius, Lithuania

[6] Univ Rzeszow, Dept Biochem & Cell Biol, Rzeszow, Poland

[7] Univ Lodz, Dept Mol Biophys, PL-90131 Lodz, Poland

来源：

FREE RADICAL RESEARCH | 2013年 / 47卷

关键词：

Glycoxidation; lipoxidation; antioxidants; cross-link breakers; proteasomes; ADVANCED GLYCATION ENDPRODUCTS; PYRIDOINDOLE ANTIOXIDANT STOBADINE; STREPTOZOTOCIN-DIABETIC RATS; PROTEIN CROSS-LINKING; TUBULAR CELL INJURY; PROMISING THERAPEUTIC STRATEGY; ISCHEMIA-REPERFUSION INJURY; UBIQUITIN-PROTEASOME SYSTEM; NON-ENZYMIC GLYCOSYLATION; GLYOXALASE-I EXPRESSION;

D O I：

10.3109/10715762.2013.792926

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand - RAGE axis.

引用

收藏

页码：93 / 137

页数：45

相关论文

共 563 条

[1] Pimagedine: a novel therapy for diabetic nephropathy [J].

Abdel-Rahman, E ;

Bolton, WK .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2002, 11 (04) :565-574

[2] The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect [J].

Adrover, Miquel ;

Vilanova, Bartolome ;

Frau, Juan ;

Munoz, Francisco ;

Donoso, Josefa .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (10) :5557-5569

[3] Unexpected isomeric equilibrium in pyridoxamine Schiff bases [J].

Adrover, Miquel ;

Vilanova, Bartolome ;

Munoz, Francisco ;

Donoso, Josefa .

BIOORGANIC CHEMISTRY, 2009, 37 (1-3) :26-32

[4] A comparative study of the chemical reactivity of pyridoxamine, Ac-Phe-Lys and Ac-Cys with various glycating carbonyl compounds [J].

Adrover, Miquel ;

Vilanova, Bartolome ;

Frau, Juan ;

Munoz, Francisco ;

Donoso, Josefa .

AMINO ACIDS, 2009, 36 (03) :437-448

[5] THE NON-ENZYMIC GLYCOSYLATION OF BOVINE LENS PROTEINS BY GLUCOSAMINE AND ITS INHIBITION BY ASPIRIN, IBUPROFEN AND GLUTATHIONE [J].

AJIBOYE, R ;

HARDING, JJ .

EXPERIMENTAL EYE RESEARCH, 1989, 49 (01) :31-41

[6] Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction? [J].

Aldini, G ;

Carini, M ;

Beretta, G ;

Bradamante, S ;

Facino, RM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 298 (05) :699-706

[7] The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats [J].

Aldini, Giancarlo ;

Orioli, Marica ;

Rossoni, Giuseppe ;

Savi, Federica ;

Braidotti, Paola ;

Vistoli, Giulio ;

Yeum, Kyung-Jin ;

Negrisoli, Gianpaolo ;

Carini, Marina .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 15 (06) :1339-1354

[8] Edaravone Inhibits Protein Carbonylation by a Direct Carbonyl-Scavenging Mechanism: Focus on Reactivity, Selectivity, and Reaction Mechanisms [J].

Aldini, Giancarlo ;

Vistoli, Giulio ;

Regazzoni, Luca ;

Benfatto, Maria Carmela ;

Bettinelli, Ilaria ;

Carini, Marina .

ANTIOXIDANTS & REDOX SIGNALING, 2010, 12 (03) :381-392

[9] A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy [J].

Alkhalaf, Alaa ;

Klooster, Astrid ;

van Oeveren, Willem ;

Achenbach, Ulrike ;

Kleefstra, Nanne ;

Slingerland, Robbert J. ;

Mijnhout, G. Sophie ;

Bilo, Henk J. G. ;

Gans, Reinold O. B. ;

Navis, Gerjan J. ;

Bakker, Stephan J. L. .

DIABETES CARE, 2010, 33 (07) :1598-1601

[10] Pyridoxamine: An extremely potent scavenger of 1,4-dicarbonyls [J].

Amarnath, V ;

Amarnath, K ;

Amarnath, K ;

Davies, S ;

Roberts, LJ .

CHEMICAL RESEARCH IN TOXICOLOGY, 2004, 17 (03) :410-415

← 1 2 3 4 5 6 7 8 9 10 →