Structure-activity relationship studies of CNS agents .32. Effect of structural modifications in 1-arylpiperazine derivatives on alpha(1)-adrenoreceptor affinity

被引：15

作者：

Mokrosz, MJ

Paluchowska, MH

CharakchievaMinol, S

Bien, A

机构：

[1] Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków

来源：

ARCHIV DER PHARMAZIE | 1997年 / 330卷 / 06期

关键词：

1-arylpiperazines; alpha(1)-adrenergic receptor affinity; 5-HT1A/alpha(1) receptor selectivity; structural modifications;

D O I：

10.1002/ardp.19973300605

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The alpha(1)-adrenergic and 5-HT1A serotonergic receptor affinities of a series of 1-arylpiperazines are presented. The role of the spacer and the influence of the terminal substituents on the alpha(1)-adrenoreceptor affinity and the 5-HT1A/alpha 1 receptor selectivity are discussed.

引用

页码：177 / 180

页数：4

共 28 条

[1]

BOJARSKI AJ, 1993, PHARMAZIE, V48, P289

[2]

BYLUND DB, 1994, PHARMACOL REV, V46, P121

[3] STUDIES ON QUINAZOLINES .5. 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES - A NOVEL CLASS OF POTENT AND SELECTIVE ALPHA(1)-ADRENOCEPTOR ANTAGONISTS AND ANTIHYPERTENSIVE AGENTS [J].