Mouse feeding behavior: ethology, regulatory mechanisms and utility for mutant phenotyping

被引：19

作者：

Heinrichs, SC ^{[1
]}

机构：

[1] Boston Coll, Dept Psychol, Chestnut Hill, MA 02467 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2001年 / 125卷 / 1-2期

关键词：

mouse feeding; obesity; knockout; mutant; phenotype;

D O I：

10.1016/S0166-4328(01)00287-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Ingestive behaviors, feeding and drinking, constitute unconditioned, obligatory functions that are tightly regulated in the rodent according to demands of the external and internal milieu. Dependent measures of food intake have been used extensively in rats to infer the identity and function of neurochemical pathways, which mediate energy balance. A recent interest in application of appetitive measures in mice can be attributed jointly to the discovery of novel markers of energy balance in genetically obese mice as well as systematic targeting of known feeding regulatory pathways in bioengineered mutant mice. Accordingly, this review will attempt to provide the reader interested in behavioral phenotyping of knockout or transgenic mice with information regarding the ethology of mouse eating behavior, known mechanisms of appetitive regulation and examples of successes and pitfalls encountered when studying food intake in mutant mice. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 88

页数：8

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