Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-α

被引：63

作者：

Hashimoto, S

Matsumoto, K

Gon, Y

Furuichi, S

Maruoka, S

Takeshita, I

Hirota, K

Yodoi, J

Horie, T

机构：

[1] Nihon Univ, Sch Med, Dept Internal Med 1, Itabashi Ku, Tokyo 1738610, Japan

[2] Kyoto Univ Hosp, Dept Anesthesia, Kyoto, Japan

[3] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Kyoto 606, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 258卷 / 02期

关键词：

D O I：

10.1006/bbrc.1999.0658

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the regulatory role of a reduction/oxidation (redox) control protein, thioredoxin (TRX), in tumor necrosis factor-alpha (TNF-alpha)-induced p38 MAP kinase activation and p38 MAP kinase-mediated cytokine expression utilizing TRX-transfected murine L929 cells (TRX14). The results showed that TNF-alpha-induced p38 MAP kinase activation and interleukin-6 (IL-6) production by TRX 14 were less than those by the parental L cells and the control transfected L cells (Neo-1). SB 203580 as the specific inhibitor for p38 MAP kinase activity inhibited TNF-alpha-induced IL-6 production by the parental L cells, indicating that TNF-alpha-activated p38 MAP kinase regulates IL-6 production by the cell lines used in this study. These results showed that overexpression of TRX negatively regulates p38 MAP kinase activation and p38 MAP kinase-mediated IL-6 production by TNF-alpha-stimulated cells, indicating that TRX is critical for p38 MAP kinase activation which regulates cytokine expression. (C) 1999 Academic Press.

引用

页码：443 / 447

页数：5

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