A highly active Suzuki catalyst for the synthesis of sterically hindered biaryls: Novel ligand coordination

被引:500
作者
Yin, JJ [1 ]
Rainka, MP [1 ]
Zhang, XX [1 ]
Buchwald, SL [1 ]
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
关键词
D O I
10.1021/ja017082r
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A catalyst system for the preparation of biaryls containing four ortho substituents via Suzuki coupling is described. The combination of a catalytic quantity of Pd2(dba)3 with either an electron-rich biarylphosphine or DPEPhos is effective using a wide range of substrates. The X-ray crystal structure of (dba)Pd(2-(9-phenanthryl)phenyl-dicyclohexylphosphine), in which the Pd is coordinated to the 9,10-double bond of the phenanthryl group, is also reported. Copyright © 2002 American Chemical Society.
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页码:1162 / 1163
页数:2
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