The Anti-stress Effects of Sarcandra glabra Extract on Restraint-Evoked Immunocompromise

被引：59

作者：

He, Rong Rong ^{[1
]}

Yao, Xin Sheng ^{[1
,2
]}

Li, Hui Ying ^{[2
]}

Dai, Yi ^{[2
]}

Duan, Ying Hui ^{[1
]}

Li, Yi Fang ^{[2
]}

Kurihara, Hiroshi ^{[2
]}

机构：

[1] Shengyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2009年 / 32卷 / 02期

关键词：

Sarcandra glabra; restraint stress; natural killer cell activity; oxygen radical absorbance capacity; antioxidation; NATURAL-KILLER-CELLS; STRESS; INFECTION; SUPPRESSION; GLYCOSIDES; CAPACITY; LEAVES; ASSAY;

D O I：

10.1248/bpb.32.247

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Sarcandra glabra was a renowned herb traditionally used as herbal tea or food supplement to enhance mental efficiency and to recover from stress or fatigue in China. We investigated the effects of Sarcandra glabra extract (SGE), with chemical composition clearly showed by HPLC fingerprint as quality control, on immunologic response including natural killer (NK) cell activity and its antioxidative capacity in splenocytes obtained front restraint mice. Our results found that daily oral administration of SGE (125, 500 mg/kg/d) for 5 consecutive days to restrained mice alleviated the stress-induced reduction of the number of lymphocytes, the balance of CD4(+) T/CD8(+) T and NK cell activity per spleen. SGE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that SGE modulate stress-attenuated immunologic response, at least, partially explained by improving antioxidative capacity in immunocytes.

引用

页码：247 / 252

页数：6

共 32 条

[1]

THE EFFECT OF VARIOUS CONTEXTS OF STRESS ON THE MOUSE SPLEEN LYMPHOCYTES AND MACROPHAGE COSTIMULATORY ACTIVITY [J].