Beyond tumor necrosis factor receptor:: TRADD signaling in toll-like receptors

被引：92

作者：

Chen, Nien-Jung ^{[1
,2
,3
]}

Chio, Iok In Christine ^{[1
,2
]}

Lin, Wen-Jye ^{[1
,2
]}

Duncan, Gordon ^{[1
,2
]}

Chau, Hien ^{[1
,2
]}

Katz, David ^{[1
,2
]}

Huang, Huey-Lan ^{[1
,2
]}

Pike, Kelly A. ^{[1
,2
]}

Hao, Zhenyue ^{[1
,2
]}

Su, Yu-Wen ^{[1
,2
]}

Yamamoto, Kazuo ^{[1
,2
]}

de Pooter, Renee F. ^{[4
]}

Zuniga-Pflucker, Juan Carlos ^{[4
]}

Wakeham, Andrew ^{[1
,2
]}

Yeh, Wen-Chen ^{[1
,2
]}

Mak, Tak W. ^{[1
,2
]}

机构：

[1] Univ Hlth Network, Campbell Family Inst Breast Canc Res, Ontario Canc Inst, Toronto, ON M5G 2C1, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada

[3] Natl Yang Ming Univ, Inst Microbiol & Immunol, Sch Life Sci, Taipei 112, Taiwan

[4] Univ Toronto, Dept Immunol, Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 34期

关键词：

TNF; innate immunity;

D O I：

10.1073/pnas.0806585105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumor necrosis factor receptor 1-associated death domain protein (TRADD) is the core adaptor recruited to TNF receptor 1 (TNFR1) upon TNF alpha stimulation. In cells from TRADD-deficient mice, TNF alpha-mediated apoptosis and TNF alpha-stimulated NF-kappa B, JNK, and ERK activation are defective. TRADD is also important for germinal center formation, DR3-mediated costimulation of T cells, and TNF alpha-mediated inflammatory responses in vivo. TRADD deficiency does not enhance IFN gamma-incluced signaling. Importantly, TRADD has a novel role in TLR3 and TLR4 signaling. TRADD participates in the TLR4 complex formed upon LPS stimulation, and TRADD-deficient macrophages show impaired cytokine production in response to TLR ligands in vitro. Thus, TRADD is a multifunctional protein crucial both for TNFR1 signaling and other signaling pathways relevant to immune responses.

引用

页码：12429 / 12434

页数：6

共 27 条

[1] Signalling pathways of the TNF superfamily: A double-edged sword [J].