Mechanism of V(D)J recombination

被引：88

作者：

Bogue, M

Roth, DB

机构：

[1] Dept. of Microbiology and Immunology, Baylor College of Medicine, Immunology M929, Houston, TX 77030

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(96)80055-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

V(D)J recombination can be separated into two basic operations: DNA cleavage and joining of broken ends. Our understanding of both reactions has increased substantially in the past year, Major advances include the development of a cell-free system capable of cleavage and the identification of several proteins involved in both V(D)J recombination and double-strand break repair.

引用

页码：175 / 180

页数：6

共 51 条

[1] SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR
BIEDERMANN, KA
SUN, JR
GIACCIA, AJ
TOSTO, LM
BROWN, JM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1394 - 1397
[2] BLIER PR, 1993, J BIOL CHEM, V268, P7594
[3] DEFECTIVE DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS LINKED TO V(D)J RECOMBINATION AND DNA-REPAIR DEFECTS ASSOCIATED WITH THE MURINE SCID MUTATION
BLUNT, T
FINNIE, NJ
TACCIOLI, GE
SMITH, GCM
DEMENGEOT, J
GOTTLIEB, TM
MIZUTA, R
VARGHESE, AJ
ALT, FW
JEGGO, PA
JACKSON, SP
[J]. CELL, 1995, 80 (05) : 813 - 823
[4] COMPLEMENTATION OF THE IONIZING-RADIATION SENSITIVITY, DNA END BINDING, AND V(D)J RECOMBINATION DEFECTS OF DOUBLE-STRAND BREAK REPAIR MUTANTS BY THE P86 KU AUTOANTIGEN
BOUBNOV, NV
HALL, KT
WILLS, Z
LEE, SE
HE, DM
BENJAMIN, DM
PULASKI, CR
BAND, H
REEVES, W
HENDRICKSON, EA
WEAVER, DT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) : 890 - 894
[5] BOUBNOV NV, 1995, MOL CELL BIOL, V15, P5700
[6] KU AUTOANTIGEN IS THE REGULATORY COMPONENT OF A TEMPLATE-ASSOCIATED PROTEIN-KINASE THAT PHOSPHORYLATES RNA POLYMERASE-II
DVIR, A
PETERSON, SR
KNUTH, MW
LU, H
DYNAN, WS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) : 11920 - 11924
[7] EZEKIEL UR, 1995, IMMUNITY, V2, P381, DOI 10.1016/1074-7613(95)90146-9
[8] DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS ABSENT IN XRS-6 CELLS - IMPLICATIONS FOR SITE-SPECIFIC RECOMBINATION AND DNA DOUBLE-STRAND BREAK REPAIR
FINNIE, NJ
GOTTLIEB, TM
BLUNT, T
JEGGO, PA
JACKSON, SP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (01) : 320 - 324
[9] THE SCID MUTATION IN MICE CAUSES A GENERAL DEFECT IN DNA-REPAIR
FULOP, GM
PHILLIPS, RA
[J]. NATURE, 1990, 347 (6292) : 479 - 482
[10] GETTS RC, 1994, J BIOL CHEM, V269, P15981

← 1 2 3 4 5 6 →