Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis

被引：115

作者：

Morisaku, Toshinori ^{[1
,2
]}

Watanabe, Junji ^{[3
]}

Konno, Tomohiro ^{[1
,2
]}

Takai, Madoka ^{[1
,2
]}

Ishihara, Kazuhiko ^{[1
,2
]}

机构：

[1] Univ Tokyo, Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138656, Japan

[3] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Osaka 5650871, Japan

来源：

POLYMER | 2008年 / 49卷 / 21期

基金：

日本科学技术振兴机构;

关键词：

2-Methacryloyloxyethyl phosphorylcholine polymer; Hydrogel; Nonfreezable water;

D O I：

10.1016/j.polymer.2008.08.025

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydration of polymer chains plays a key role for determining the extent of protein adsorption on polymeric materials. Here we investigated the hydration of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) chains, which resist protein adsorption and following cell adhesion effectively. The hydration was compared with that of poly(methoxy oligo(ethylene glycol)-monomethacrylate (Me(EG)(n)MA)) chains, which also have hydrophilic units. The poly(MPC) and poly(Me(EG)(n)MA) hydrogels with equilibrium water contents (EWCs) in the range from 86 to 97 wt% were prepared. By differential scanning calorimetric measurements, water in both the hydrogels was classified into two states: freezable and nonfreezable water. The poly(MPC) hydrogels had larger nonfreezable water than the poly(Me(EG),MA) hydrogels even when their EWCs were similar, which indicated the higher hydrating ability of poly(MPC) chains. We suggested that the difference in the amount of nonfreezable water around polymer chains may influence the degree of protein adsorption resistance after contact with body fluid for a long period. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4652 / 4657

页数：6

共 31 条

[1]

Antonsen K.P., 1992, Poly (Ethylene Glycol) Chemistry, P15, DOI [10.1007/978-1-4899-0703-5_2, DOI 10.1007/978-1-4899-0703-5_2]

[2] Exploiting the current paradigm of blood-material interactions for the rational design of blood-compatible materials [J].

Brash, JL .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2000, 11 (11) :1135-1146

[3] Geometric control of cell life and death [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

SCIENCE, 1997, 276 (5317) :1425-1428

[4] Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials [J].

Chen, SF ;

Zheng, J ;

Li, LY ;

Jiang, SY .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (41) :14473-14478

[5] Protein resistant surfaces: Comparison of acrylate graft polymers bearing oligo-ethylene oxide and phosphorylcholine side chains [J].

Feng, Wei ;

Zhu, Shiping ;

Ishihara, Kazuhiko ;

Brash, John L. .

BIOINTERPHASES, 2006, 1 (01) :50-60

[6] Zwitterionic SAMs that resist nonspecific adsorption of protein from aqueous buffer [J].

Holmlin, RE ;

Chen, XX ;

Chapman, RG ;

Takayama, S ;

Whitesides, GM .

LANGMUIR, 2001, 17 (09) :2841-2850

[7]

Huang L, 2001, J POLYM SCI POL PHYS, V39, P496, DOI 10.1002/1099-0488(20010301)39:5<496::AID-POLB1023>3.0.CO

[8]

2-H

[9] PREPARATION OF PHOSPHOLIPID POLYMERS AND THEIR PROPERTIES AS POLYMER HYDROGEL MEMBRANES [J].

ISHIHARA, K ;

UEDA, T ;

NAKABAYASHI, N .

POLYMER JOURNAL, 1990, 22 (05) :355-360

[10] Photoinduced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on polyethylene membrane surface for obtaining blood cell adhesion resistance [J].

Ishihara, K ;

Iwasaki, Y ;

Ebihara, S ;

Shindo, Y ;

Nakabayashi, N .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2000, 18 (3-4) :325-335

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