Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: Insights into nonfouling properties of zwitterionic materials

被引：917

作者：

Chen, SF ^{[1
]}

Zheng, J ^{[1
]}

Li, LY ^{[1
]}

Jiang, SY ^{[1
]}

机构：

[1] Univ Washington, Dept Chem Engn, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 41期

关键词：

D O I：

10.1021/ja054169u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMS) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

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收藏

页码：14473 / 14478

页数：6

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