MicroRNAs in cell proliferation, cell death, and tumorigenesis

被引：1140

作者：

Hwang, HW ^{[1
]}

Mendell, JT ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Med Genet, Program Human Genet & Mol Biol, Baltimore, MD 21205 USA

来源：

BRITISH JOURNAL OF CANCER | 2006年 / 94卷 / 06期

关键词：

microRNAs; cellular proliferation; apoptosis; oncogene; tumour suppressor;

D O I：

10.1038/sj.bjc.6603023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs ( miRNAs) are a recently discovered class of similar to 18 - 24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

引用

页码：776 / 780

页数：5

共 38 条

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