Transcriptional and Posttranslational Modifications of Titin Implications for Diastole

被引：31

作者：

Borbely, Attila ^{[1
,2
]}

van Heerebeek, Loek ^{[1
]}

Paulus, Walter J. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Physiol, Inst Cardiovasc Res, NL-1081 BT Amsterdam, Netherlands

[2] Univ Debrecen, Inst Cardiol, Debrecen, Hungary

来源：

CIRCULATION RESEARCH | 2009年 / 104卷 / 01期

关键词：

diastole; titin; myocardium; heart failure; myofilaments; PASSIVE STIFFNESS; PHOSPHORYLATION; EXPRESSION; MUSCLE;

D O I：

10.1161/CIRCRESAHA.108.191130

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：12 / 14

页数：3

共 17 条

[1] Enhanced nitrosative stress during Trypanosoma cruzi infection causes nitrotyrosine modification of host proteins -: Implications in Chagas' disease [J].

Dhiman, Monisha ;

Nakayasu, Ernesto Satoshi ;

Madaiah, Yashoda Hosakote ;

Reynolds, Brobey K. ;

Wen, Jian-jun ;

Almeida, Igor Correia ;

Garg, Nisha Jain .

AMERICAN JOURNAL OF PATHOLOGY, 2008, 173 (03) :728-740

[2] Ca2+-Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy [J].

Flagg, Thomas P. ;

Cazorla, Olivier ;

Remedi, Maria S. ;

Haim, Todd E. ;

Tones, Michael A. ;

Bahinski, Anthony ;

Numann, Randal E. ;

Kovacs, Attila ;

Schaffer, Jean E. ;

Nichols, Colin G. ;

Nerbonne, Jeanne M. .

CIRCULATION RESEARCH, 2009, 104 (01) :95-U245

[3] Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner [J].

Fukuda, N ;

Wu, YM ;

Nair, P ;

Granzier, HL .

JOURNAL OF GENERAL PHYSIOLOGY, 2005, 125 (03) :257-271

[4] What mechanisms underlie diastolic dysfunction in heart failure? [J].

Kass, DA ;

Bronzwaer, JGF ;

Paulus, WJ .

CIRCULATION RESEARCH, 2004, 94 (12) :1533-1542

[5] Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/AKT pathway [J].

Krueger, Martina ;

Sachse, Christine ;

Zimmermann, Wolfram H. ;

Eschenhagen, Thomas ;

Klede, Stefanie ;

Linke, Wolfgang A. .

CIRCULATION RESEARCH, 2008, 102 (04) :439-447

[6] Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension [J].

Krueger, Martina ;

Linke, Wolfgang A. .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2006, 27 (5-7) :435-444

[7] Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs [J].

Krueger, Martina ;

Koetter, Sebastian ;

Gruetzner, Anika ;

Lang, Patrick ;

Andresen, Christian ;

Redfield, Margaret M. ;

Butt, Elke ;

dos Remedios, Cris G. ;

Linke, Wolfgang A. .

CIRCULATION RESEARCH, 2009, 104 (01) :87-U230

[8] Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium [J].

Linke, WA ;

Fernandez, JM .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2002, 23 (5-6) :483-497

[9] Actin-titin interaction in cardiac myofibrils: Probing a physiological role [J].

Linke, WA ;

Ivemeyer, M ;

Labeit, S ;

Hinssen, H ;

Ruegg, JC ;

Gautel, M .

BIOPHYSICAL JOURNAL, 1997, 73 (02) :905-919

[10] Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts [J].

Makarenko, I ;

Opitz, CA ;

Leake, MC ;

Neagoe, C ;

Kulke, M ;

Gwathmey, JK ;

del Monte, F ;

Hajjar, RJ ;

Linke, WA .

CIRCULATION RESEARCH, 2004, 95 (07) :708-716

← 1 2 →