FAK and PYK2/CAKβ in the nervous system:: a link between neuronal activity, plasticity and survival?

被引：164

作者：

Girault, JA ^{[1
]}

Costa, A ^{[1
]}

Derkinderen, P ^{[1
]}

Studler, JM ^{[1
]}

Toutant, M ^{[1
]}

机构：

[1] INSERM, U114, Coll France, F-75005 Paris, France

来源：

TRENDS IN NEUROSCIENCES | 1999年 / 22卷 / 06期

关键词：

D O I：

10.1016/S0166-2236(98)01358-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A major aim of neurobiology today is to improve understanding of the signaling pathways that couple rapid events, such as the action potential and neurotransmitter release, to long-lasting changes in synaptic strength and increased neuronal survival. These adaptations involve interactions of neurons with other cells and with the extracellular matrix,They use, in part, the same molecular machinery that controls adhesion, motility or survival in non-neuronal cells,This machinery includes two homologous non-receptor tyrosine kinases, FAK and PYK2/CAK beta, and the associated SRC-family tyrosine kinases, Specific brain isoforms of FAK with distinct properties are regulated by neurotransmitters, whereas PYK2/CAK beta is highly sensitive to depolarization. The multiplicity of the pathways that can be activated by these tyrosine kinases indicates their importance in signal transduction in the adult brain.

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页码：257 / 263

页数：7

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