Mechanisms of subcellular mRNA localization

被引:258
作者
Kloc, M [1 ]
Zearfoss, NR [1 ]
Etkin, LD [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
关键词
D O I
10.1016/S0092-8674(02)00651-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Localization of RNA is a widespread and efficient way to target gene products to a specific region of a cell or embryo. This strategy of posttranscriptional gene regulation utilizes a variety of distinct mechanisms to regulate the movement and anchoring of different transcripts.
引用
收藏
页码:533 / 544
页数:12
相关论文
共 93 条
[81]   Protein synthesis at synaptic sites on dendrites [J].
Steward, O ;
Schuman, EM .
ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :299-325
[82]   Synaptic activation causes the mRNA for the IEG Arc to localise selectively near activated postsynaptic sites on dendrites [J].
Steward, O ;
Wallace, CS ;
Lyford, GL ;
Worley, PF .
NEURON, 1998, 21 (04) :741-751
[83]   The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p [J].
Takizawa, PA ;
Vale, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5273-5278
[84]   Localization of gurken RNA in Drosophila oogenesis requires elements in the 5′ and 3′ regions of the transcript [J].
Thio, GL ;
Ray, RP ;
Barcelo, G ;
Schüpbach, T .
DEVELOPMENTAL BIOLOGY, 2000, 221 (02) :435-446
[85]   A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation [J].
Tomancak, P ;
Piano, F ;
Riechmann, V ;
Gunsalus, KC ;
Kemphues, KJ ;
Ephrussi, A .
NATURE CELL BIOLOGY, 2000, 2 (07) :458-460
[86]   Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes [J].
Wilhelm, JE ;
Vale, RD ;
Hegde, RS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13132-13137
[87]   Drosophila wingless and pair-rule transcripts localize apically by dynein-mediated transport of RNA particles [J].
Wilkie, GS ;
Davis, I .
CELL, 2001, 105 (02) :209-219
[88]   CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of α-CaMKII mRNA at synapses [J].
Wu, L ;
Wells, D ;
Tay, J ;
Mendis, D ;
Abbott, MA ;
Barnitt, A ;
Quinlan, E ;
Heynen, A ;
Fallon, JR ;
Richter, JD .
NEURON, 1998, 21 (05) :1129-1139
[89]  
Yaniv K, 2001, INT REV CYTOL, V203, P521
[90]  
YISRAELI JK, 1990, DEVELOPMENT, V108, P289