Effect of estradiol valerate on endometrium thickness during clomiphene citrate-stimulated ovulation

被引:62
作者
Satirapod, Chonthicha [1 ]
Wingprawat, Siripen [1 ]
Jultanmas, Rattiya [2 ]
Rattanasiri, Sasivimol [3 ]
Jirawatnotai, Siwanon [4 ]
Choktanasiri, Wicharn [1 ]
机构
[1] Ramathibodi Hosp, Dept Obstet & Gynaecol, Fac Med, Bangkok 10400, Thailand
[2] Ramathibodi Hosp, Dept Nursing, Fac Med, Bangkok 10400, Thailand
[3] Ramathibodi Hosp, Res Ctr, Fac Med, Bangkok 10400, Thailand
[4] Mahidol Univ, Dept Pharmacol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
关键词
clomiphene citrate; endometrial thickness; estradiol valerate; folliculogenesis; ovarian stimulation; HUMAN MENOPAUSAL GONADOTROPINS; EMBRYO REPLACEMENT CYCLES; INTRAUTERINE INSEMINATION; ETHINYL ESTRADIOL; SONOGRAPHIC ASSESSMENT; GNRH ANTAGONIST; CERVICAL-MUCUS; PATTERN; WOMEN; INDUCTION;
D O I
10.1111/jog.12130
中图分类号
R71 [妇产科学];
学科分类号
100211 [妇产科学];
摘要
AimThe aim of this study was to examine the effects of estradiol valerate (EV) on the thickness of clomiphene citrate (CC)-stimulated endometrium. Material and MethodsThirty-four normal ovulatory women were randomized double-blindly into two groups to receive CC 100mg/day on day 2-6 of the treatment cycle, and either vitamin B (placebo) or EV 6mg/day on day 10-14 of the cycle. The endometrial thickness, endometrial pattern, numbers of mature follicles, and maximal diameters of preovulatory follicles were evaluated by transvaginal sonographic examination. ResultsThirty women completed both treatment cycles. Two other participants dropped out during the treatment due to side-effects (headache). The average endometrial thickness of the group treated with CC+placebo became slightly thinner when compared to the thickness at the baseline (9.04 vs 9.52mm; P=0.24). The CC+placebo and the CC+EV resulted in similar endometrial pattern, ovulation day, numbers of mature follicles, and sizes of the leading follicles before ovulation. However, an addition of EV into the CC cycle significantly increased the average endometrial thickness (10.7mm vs 9.04mm; P<0.001). ConclusionsWe concluded that the addition of 6mg/day EV following the CC treatment can prevent the endometrial thinning without perturbing folliculogenesis and ovulation.
引用
收藏
页码:96 / 101
页数:6
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