Cyclic GMP regulates cromakalim-induced relaxation in the rat aortic smooth muscle:: Role of cyclic GMP in KATP-channels

被引:13
作者
Wu, CC
Chen, SJ
Yen, MH
机构
[1] Natl Def Med Ctr, Dept Pharmacol, Taipei, Taiwan
[2] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan
关键词
cromakalim; cyclic GMP; K-ATP-channels; rat aorta;
D O I
10.1016/S0024-3205(99)00204-0
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Recent studies have shown that nitric oxide (NO) modulates K+-channel activity which play an important role in controlling vascular tone. The formation of cyclic guanosine 3',5'-monophosphate (cyclic GMP) has also been recognized to be associated with the vasodilatory effect of NO. Both cyclic GMP and NO increase whole-cell K+-current by activating Ca2+-activated K+-channels (K-Ca-channels). Here, we show evidence that activators of soluble guanylyl cyclase sodium nitroprusside or 3-morpholino-sydnonimine (SIN-1), and an analogue of cyclic GMP 8-bromo-cyclic GMP enhance the relaxation induced by cromakalim which is blocked by glibenclamide (a specific inhibitor of ATP-sensitive K+-channels [K-ATP-channels]), and partially attenuated by methylene blue (an inhibitor of cyclic CMP formation). However, this is not due to the increase of cyclic GMP level by cromakalim itself because the relaxation induced by cromakalim is not associated with the changes of cyclic GMP level formed in the aortic smooth muscle. Thus, it is most likely that cyclic GMP also modulates activity of K-ATP-channels, in addition to K-Ca-channels, in the rat aorta.
引用
收藏
页码:2471 / 2478
页数:8
相关论文
共 28 条
[21]   MAXI K+ CHANNELS ARE STIMULATED BY CYCLIC GUANOSINE MONOPHOSPHATE-DEPENDENT PROTEIN-KINASE IN CANINE CORONARY-ARTERY SMOOTH-MUSCLE CELLS [J].
TANIGUCHI, J ;
FURUKAWA, K ;
SHIGEKAWA, M .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 423 (3-4) :167-172
[22]   HYPERPOLARIZATION AND RELAXATION OF ARTERIAL SMOOTH-MUSCLE CAUSED BY NITRIC-OXIDE DERIVED FROM THE ENDOTHELIUM [J].
TARE, M ;
PARKINGTON, HC ;
COLEMAN, HA ;
NEILD, TO ;
DUSTING, GJ .
NATURE, 1990, 346 (6279) :69-71
[23]  
Thiemermann C, 1994, Adv Pharmacol, V28, P45, DOI 10.1016/S1054-3589(08)60493-7
[24]   INTRACELLULAR MECHANISMS INVOLVED IN THE REGULATION OF VASCULAR SMOOTH-MUSCLE TONE [J].
WALSH, MP ;
KARGACIN, GJ ;
KENDRICKJONES, J ;
LINCOLN, TM .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1995, 73 (05) :565-573
[25]   Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats [J].
Wu, CC ;
Hong, HJ ;
Chou, TZ ;
Ding, YA ;
Yen, MH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 228 (02) :459-466
[26]   Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats [J].
Wu, CC ;
Chen, SJ ;
Yen, MH .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (04) :H1148-H1157
[27]   GLIBENCLAMIDE-INDUCED INHIBITION OF THE EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN CULTURED MACROPHAGES AND IN THE ANESTHETIZED RAT [J].
WU, CC ;
THIEMERMANN, C ;
VANE, JR .
BRITISH JOURNAL OF PHARMACOLOGY, 1995, 114 (06) :1273-1281
[28]   PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A CGMP-GATED POTASSIUM CHANNEL [J].
YAO, XQ ;
SEGAL, AS ;
WELLING, P ;
ZHANG, XQ ;
MCNICHOLAS, CM ;
ENGEL, D ;
BOULPAEP, EL ;
DESIR, GV .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11711-11715