On the putative co-transport of drugs by multidrug resistance proteins

被引：58

作者：

Borst, P

Zelcer, N

van de Wetering, K

Poolman, B

机构：

[1] Netherlands Canc Inst, Div Mol Biol, Biomed Genet Ctr, NL-1066 CX Amsterdam, Netherlands

[2] Univ Calif Los Angeles, Dept Pathol & Lab Med, Howard Hughes Med Inst, MacDonald Res Labs, Los Angeles, CA 90095 USA

[3] MSC, Dept Biochem, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands

来源：

FEBS LETTERS | 2006年 / 580卷 / 04期

关键词：

ABC transporters; homotropic cooperativity; heterotropic cooperativity; transport kinetics; MRPs;

D O I：

10.1016/j.febslet.2005.12.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experiments with multidrug resistance-associated protein I (MRP1) showed 10-years ago that transport of vincristine (VCR) by MRP1 could be stimulated by GSH, and transport of GSH by VCR. Since then many examples of stimulated transport have been reported for MRP1, 2, 3, 4 and 8. We discuss here three models to explain stimulated transport. We favour a model in which a large promiscuous binding site can bind more than one ligand, allowing cooperative/competitive interactions between ligands within the binding site. We conclude that there is no unambiguous proof for co-transport of two different ligands by MRPs, but that cross-stimulated transport can explain the published data. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：1085 / 1093

页数：9

相关论文

共 51 条

[41] Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1 [J].

Qian, YM ;

Song, WC ;

Cui, H ;

Cole, SPC ;

Deeley, RG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (09) :6404-6411

[42] The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs [J].

Reid, G ;

Wielinga, P ;

Zelcer, N ;

van der Heijden, I ;

Kuil, A ;

de Haas, M ;

Wijnholds, J ;

Borst, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9244-9249

[43] The (patho)physiological functions of the MRP family [J].

Renes, J ;

de Vries, EGE ;

Jansen, PLM ;

Müller, M .

DRUG RESISTANCE UPDATES, 2000, 3 (05) :289-302

[44] Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane [J].

Rius, M ;

Nies, AT ;

Hummel-Eisenbeiss, J ;

Jedlitschky, G ;

Keppler, D .

HEPATOLOGY, 2003, 38 (02) :374-384

[45]

Sakamoto H, 1999, CANCER LETT, V135, P113

[46] Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions [J].

Tang, W ;

Stearns, RA .

CURRENT DRUG METABOLISM, 2001, 2 (02) :185-198

[47] Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites [J].

Van Aubel, RAMH ;

Smeets, PHE ;

van den Heuvel, JJMW ;

Russel, FGM .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (02) :F327-F333

[48] Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells [J].

Wielinga, PR ;

van der Heijden, I ;

Reid, G ;

Beijnen, JH ;

Wijnholds, J ;

Borst, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (20) :17664-17671

[49] Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4) [J].

Zelcer, N ;

Reid, G ;

Wielinga, P ;

Kuil, A ;

Van Der Heijden, I ;

Schuetz, JD ;

Borst, P .

BIOCHEMICAL JOURNAL, 2003, 371 :361-367

[50] Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) [J].

Zelcer, N ;

Huisman, MT ;

Reid, G ;

Wieling, P ;

Breedveld, P ;

Kuil, A ;

Knipscheer, P ;

Schellens, JHM ;

Schinkel, AH ;

Borst, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (26) :23538-23544

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