MicroRNA in Alzheimer's disease: an exploratory study in brain, cerebrospinal fluid and plasma

被引：91

作者：

Bekris, Lynn M. ^{[1
,2
,3
,4
]}

Lutz, Franziska ^{[1
,2
,3
,4
]}

Montine, Thomas J. ^{[5
]}

Yu, Chang En ^{[1
,2
,3
,4
]}

Tsuang, Debby ^{[1
,2
,3
,6
,7
,8
,9
]}

Peskind, Elaine R. ^{[6
,7
,8
,9
]}

Leverenz, James B. ^{[1
,2
,3
,6
,7
,8
,9
,10
,11
,12
,13
]}

机构：

[1] VA Puget Sound Hlth Care Syst, Dept Geriatr GRECC, Res Ctr, Seattle, WA USA

[2] VA Puget Sound Hlth Care Syst, Dept Geriatr GRECC, Educ Ctr, Seattle, WA USA

[3] VA Puget Sound Hlth Care Syst, Dept Geriatr GRECC, Ctr Clin, Seattle, WA USA

[4] Univ Washington, Dept Med, Seattle, WA 98108 USA

[5] Univ Washington, Dept Pathol, Seattle, WA 98108 USA

[6] VA Puget Sound Hlth Care Syst, Dept Mental Illness MIRECC, Res Ctr, Seattle, WA USA

[7] VA Puget Sound Hlth Care Syst, Dept Mental Illness MIRECC, Educ Ctr, Seattle, WA USA

[8] VA Puget Sound Hlth Care Syst, Dept Mental Illness MIRECC, Ctr Clin, Seattle, WA USA

[9] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA

[10] VA Puget Sound Hlth Care Syst, Dept Parkinsons Dis PADRECC, Res Ctr, Seattle, WA USA

[11] VA Puget Sound Hlth Care Syst, Dept Parkinsons Dis PADRECC, Educ Ctr, Seattle, WA USA

[12] VA Puget Sound Hlth Care Syst, Dept Parkinsons Dis PADRECC, Ctr Clin, Seattle, WA USA

[13] Univ Washington, Dept Neurol, Seattle, WA 98108 USA

来源：

BIOMARKERS | 2013年 / 18卷 / 05期

关键词：

Amyloid; biomarker; braak stage; miR-15a; miR-370; miR-328; miR-138; miR-132; plaque; ENDOGENOUS CONTROL GENES; NEUROPATHOLOGIC ASSESSMENT; PROSTATE-CANCER; NEURONAL LOSS; EXPRESSION; IDENTIFICATION; DEMENTIA; MIRNA; BIOMARKERS; DIAGNOSIS;

D O I：

10.3109/1354750X.2013.814073

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

MicroRNA (miRNA) may be potential biomarkers of Alzheimer's disease (AD). The objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage. Post-mortem brain (PMB) miRNA were profiled using arrays and validated using quantitative RT-PCR (qRT-PCR). Five gRT-PCR-validated miRNAs were measured in an independent sample of PMB, cerebrospinal fluid and plasma from the same subjects. Plasma miR-15a was found to be associated with plaque score in the independent sample. In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD.

引用

页码：455 / 466

页数：12

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